https://pharmacopedia.wiki/index.php?action=history&feed=atom&title=Receptor%3A5-HT1A 2026-05-28T07:32:39Z Revision history for this page on the wiki MediaWiki 1.46.0-beta https://pharmacopedia.wiki/index.php?title=Receptor:5-HT1A&diff=5672&oldid=prev 2026-05-22T06:12:29Z

<p>Create receptor entity seed stub</p> <p><b>New page</b></p><div>&#039;&#039;&#039;5-HT1A&#039;&#039;&#039; is a G protein-coupled [[Serotonin|serotonin]] receptor and the most extensively studied member of the 5-HT1 receptor family, which couples to inhibitory Gi/o proteins and suppresses [[Adenylyl cyclase|adenylyl cyclase]] activity.&lt;ref name=&quot;hoyer2002&quot;&gt;Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry, and Behavior. 2002 Apr;71(4):533-554. PMID: 11888546.&lt;/ref&gt; It is expressed both as a somatodendritic autoreceptor on [[Raphe nuclei|raphe]] serotonergic neurons, where it regulates serotonergic tone, and as a postsynaptic receptor in the hippocampus, cortex, and limbic regions. 5-HT1A is the principal target of the anxiolytic [[Buspirone|buspirone]] and contributes to the action of several antidepressants; partial agonism at 5-HT1A is part of the receptor profile of the serotonergic psychedelics.<br /> <br /> This page is a seed stub.<br /> <br /> == References ==<br /> &lt;references/&gt;<br /> <br /> [[Category:Receptors]]</div>

MDElliottMD