Rimegepant - Revision history

MDElliottMD: parser-claude: Rimegepant MedTemplate refill, Top 300 stub upgrade

2026-05-23T07:21:22Z

parser-claude: Rimegepant MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 07:21, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Rimegepant		\| generic = Rimegepant
	\| brand = Nurtec		\| brand = Nurtec ODT
	\| structure =		\| structure =
	\| classes = Gepant, ~~Migraine~~ medicine		\| classes = [[:Category:Gepants\|Gepant (small-molecule CGRP receptor antagonist)]], [[:Category:Antimigraine medicines\|Antimigraine medicine]], [[:Category:Analgesics\|Analgesic]]
	\| ~~mechanism = CGRP receptor antagonist~~		\| uses = <vote slug="acute-migraine-use">Acute migraine with or without aura (FDA, 2020)</vote>, <vote slug="migraine-prophylaxis-use">Migraine preventive treatment (FDA, 2021; '''the first medicine with both acute and preventive migraine indications''')</vote>
	\| uses =		\| starting_dose = Acute migraine: 75 mg PO at onset, maximum one dose per 24 hours. Preventive: 75 mg PO every other day
	\| starting_dose =		\| preparations = Orally disintegrating tablet 75 mg
	\| preparations =		\| fda_max = 75 mg per dose; one dose per 24 hours (acute); one dose every other day (preventive)
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral (sublingual disintegration)
	\| onset =		\| onset = 1-2 hours for migraine relief
	\| duration =		\| duration = ~48 hours of headache freedom
	\| halflife =		\| halflife = ~11 hours<ref name="nurtec-label">FDA Prescribing Information, Nurtec ODT (rimegepant), Biohaven/Pfizer, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212728s003lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~64% (oral)<ref name="nurtec-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US
	\| ~~intro =~~		\| mechanism = <vote slug="rimegepant-mech-claim">Small-molecule antagonist of the calcitonin gene-related peptide (CGRP) receptor, the first oral CGRP-targeting agent in widespread clinical use. CGRP is the dominant pro-migraine neuropeptide released from trigeminal nerve terminals; blocking its receptor blunts the neurogenic inflammation that drives migraine pain.</vote> '''Unlike triptans, rimegepant does not cause vasoconstriction''' and is safe in patients with coronary artery disease and other vascular conditions where triptans are contraindicated. The dual acute-and-preventive indication is the unique pharmacological feature among migraine medicines. The second-generation gepants (rimegepant, ubrogepant, atogepant) have a clean hepatic-safety profile compared to the first-generation gepants withdrawn during development for hepatotoxicity<ref name="nurtec-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects =~~
	\| ~~interactions~~ = <~~pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	~~\| monitoring =~~
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:~~Antimigraine agents~~]]		[[Category:Gepants]]
	[[Category:~~Gepants (CGRP Receptor Antagonists)~~]]		[[Category:Antimigraine medicines]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

2026-05-22T00:37:23Z

Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

← Older revision		Revision as of 00:37, 22 May 2026
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	[[Category:~~Migraine Medicines~~]]		[[Category:Antimigraine agents]]
	[[Category:Gepants (CGRP Receptor Antagonists)]]		[[Category:Gepants (CGRP Receptor Antagonists)]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:07:08Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:07, 14 May 2026
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	}}		}}


			[[Category:Migraine Medicines]]
			[[Category:Gepants (CGRP Receptor Antagonists)]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:08Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:49Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:57Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Rimegepant
+| generic            = Rimegepant
-| brand             = Nurtec
+| brand              = Nurtec
-| classes           = Gepant, Migraine medicine
+| structure          =
-| mechanism         = CGRP receptor antagonist
+| classes            = Gepant, Migraine medicine
 }}
 [[Category:Analgesics]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Rimegepant
| brand = Nurtec
| classes = Gepant, Migraine medicine
| mechanism = CGRP receptor antagonist
}}
[[Category:Analgesics]]