MDElliottMD: Create stub: Serotonin syndrome (backs redlinks; Boyer 2005 NEJM cited)

2026-05-22T00:18:08Z

Create stub: Serotonin syndrome (backs redlinks; Boyer 2005 NEJM cited)

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'''Serotonin syndrome''' is a potentially serious, sometimes life-threatening condition caused by excessive serotonergic activity in the central nervous system. It most often arises when two or more serotonergic medicines are combined, or when one is taken in overdose.<ref name="boyer2005">Boyer EW, Shannon M. The serotonin syndrome. New England Journal of Medicine. 2005 Mar 17;352(11):1112-1120. PMID 15784664.</ref>

It is characterized by a triad of neuromuscular abnormality (tremor, clonus, hyperreflexia, rigidity), autonomic instability (tachycardia, hypertension, hyperthermia, diaphoresis), and altered mental status (agitation, confusion); severity ranges from mild to fatal. Medicine classes commonly implicated include the [[:Category:Selective Serotonin Reuptake Inhibitors (SSRIs)|SSRIs]], [[:Category:Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs)|SNRIs]], and [[:Category:Monoamine Oxidase Inhibitors (MAOIs)|MAOIs]], along with [[Tramadol|tramadol]] and [[Dextromethorphan|dextromethorphan]]; this risk is the basis of many of the interaction cautions noted across this wiki.

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== References ==
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Serotonin syndrome - Revision history

MDElliottMD: Create stub: Serotonin syndrome (backs redlinks; Boyer 2005 NEJM cited)