MDElliottMD: home-claude house-rule fix (terminology / spelling)

2026-05-23T04:44:07Z

home-claude house-rule fix (terminology / spelling)

← Older revision		Revision as of 04:44, 23 May 2026
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	\| structure =		\| structure =
	\| classes = [[:Category:Crystalloid_IV_fluids\|Crystalloid IV fluid]], [[:Category:Electrolyte_replacements\|Electrolyte replacement]]		\| classes = [[:Category:Crystalloid_IV_fluids\|Crystalloid IV fluid]], [[:Category:Electrolyte_replacements\|Electrolyte replacement]]
	\| uses = <vote slug="volume-resuscitation-use">Volume resuscitation</vote>, <vote slug="maintenance-iv-fluid-use">Maintenance IV fluid</vote>, <vote slug="hyponatremia-use">Hyponatremia (3% hypertonic for symptomatic)</vote>, <vote slug="cystic-fibrosis-airway-clearance-use">Nebulized 3-7% for cystic fibrosis airway clearance</vote>, <vote slug="iv-medication-diluent-use">IV ~~medication~~ diluent</vote>		\| uses = <vote slug="volume-resuscitation-use">Volume resuscitation</vote>, <vote slug="maintenance-iv-fluid-use">Maintenance IV fluid</vote>, <vote slug="hyponatremia-use">Hyponatremia (3% hypertonic for symptomatic)</vote>, <vote slug="cystic-fibrosis-airway-clearance-use">Nebulized 3-7% for cystic fibrosis airway clearance</vote>, <vote slug="iv-medication-diluent-use">IV medicine diluent</vote>
	\| starting_dose = Volume and concentration titrated to clinical status; symptomatic hyponatremia: 3% NaCl 100-150 mL bolus, reassess		\| starting_dose = Volume and concentration titrated to clinical status; symptomatic hyponatremia: 3% NaCl 100-150 mL bolus, reassess
	\| preparations = 0.225%, 0.45%, 0.9%, 3%, 5% IV solutions; 0.9% nasal spray; 3% and 7% nebulizer solutions; oral tablets (1 g)		\| preparations = 0.225%, 0.45%, 0.9%, 3%, 5% IV solutions; 0.9% nasal spray; 3% and 7% nebulizer solutions; oral tablets (1 g)

MDElliottMD: home-claude punt-list stub-split, Top 300 #227

2026-05-23T04:41:15Z

home-claude punt-list stub-split, Top 300 #227

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Sodium chloride is the principal extracellular electrolyte salt, used clinically as an intravenous crystalloid (most commonly 0.9% "normal saline"), oral or parenteral electrolyte replacement, hypertonic solution for symptomatic hyponatremia, nebulized irrigant in cystic fibrosis and bronchiectasis, ophthalmic decongestant, and pharmaceutical diluent<ref name="nacl-label">FDA Prescribing Information, 0.9% Sodium Chloride Injection, Baxter, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/018324s039lbl.pdf</ref>. Normal saline (154 mEq/L Na+ and 154 mEq/L Cl-) is the most widely administered medicinal product in the world.

{{MedTemplate
| generic = Sodium chloride
| brand = Normal saline, NaCl injection, many; nebulized: HyperSal, PulmoSal
| structure =
| classes = [[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]], [[:Category:Electrolyte_replacements|Electrolyte replacement]]
| uses = <vote slug="volume-resuscitation-use">Volume resuscitation</vote>, <vote slug="maintenance-iv-fluid-use">Maintenance IV fluid</vote>, <vote slug="hyponatremia-use">Hyponatremia (3% hypertonic for symptomatic)</vote>, <vote slug="cystic-fibrosis-airway-clearance-use">Nebulized 3-7% for cystic fibrosis airway clearance</vote>, <vote slug="iv-medication-diluent-use">IV medication diluent</vote>
| starting_dose = Volume and concentration titrated to clinical status; symptomatic hyponatremia: 3% NaCl 100-150 mL bolus, reassess
| preparations = 0.225%, 0.45%, 0.9%, 3%, 5% IV solutions; 0.9% nasal spray; 3% and 7% nebulizer solutions; oral tablets (1 g)
| fda_max = No fixed maximum; titrated; sodium correction rate in chronic hyponatremia must not exceed 8-10 mEq/L per 24 hours to avoid osmotic demyelination
| pill_id =
| routes = IV, oral, nebulized, intranasal, ophthalmic
| onset = Immediate (IV)
| duration = Roughly 20-25% of an IV bolus remains intravascular at 1 hour
| halflife = Not applicable (electrolyte)
| bioavailability = 100% (IV); essentially complete (oral)
| pregnancy = Standard fluid and electrolyte management
| legal = [[USLegal:Prescription only|Rx-only]] for parenteral formulations; OTC for oral, nasal, and many nebulizer products
| mechanism = <vote slug="nacl-mech-claim">Sodium chloride solutions expand the extracellular volume in proportion to their tonicity; high-volume 0.9% saline reliably produces hyperchloremic metabolic acidosis, which is why balanced crystalloids like Lactated Ringer's are often preferred for large-volume resuscitation.</vote> Hypertonic 3% is the standard urgent treatment of severely symptomatic hyponatremia<ref name="nacl-label" />.
}}

== References ==
<references />

Sodium Chloride - Revision history

MDElliottMD: home-claude house-rule fix (terminology / spelling)

MDElliottMD: home-claude punt-list stub-split, Top 300 #227