Sumatriptan - Revision history

MDElliottMD: parser-claude: Sumatriptan MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:59:50Z

parser-claude: Sumatriptan MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:59, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Sumatriptan		\| generic = Sumatriptan (succinate)
	\| brand = Imitrex		\| brand = Imitrex (oral, injectable, nasal), Tosymra (nasal spray), Onzetra Xsail (nasal powder), Zembrace SymTouch (low-dose autoinjector), Sumavel DosePro (needle-free SC)
	\| structure =		\| structure =
	\| classes = Triptan~~, Migraine medicine~~		\| classes = [[:Category:Triptans\|Triptan (5-HT1B/1D agonist)]], [[:Category:Antimigraine medicines\|Antimigraine medicine]], [[:Category:Analgesics\|Analgesic]]
	~~\| mechanism =~~ 5-HT1B/1D agonist		\| uses = <vote slug="acute-migraine-use">Acute migraine with or without aura (FDA)</vote>, <vote slug="cluster-headache-use">Cluster headache (FDA; subcutaneous and nasal formulations specifically)</vote>
	\| uses =		\| starting_dose = Oral: 50-100 mg at migraine onset, may repeat in 2 hours if needed. SC: 6 mg, may repeat in 1 hour. Nasal: 5-20 mg per nostril, may repeat in 2 hours
	\| starting_dose =		\| preparations = Oral tablets 25, 50, 100 mg; SC injection 4, 6 mg autoinjector; needle-free SC 6 mg (Sumavel); nasal spray 5, 20 mg; nasal powder 22 mg (Onzetra Xsail); low-dose autoinjector 3 mg (Zembrace SymTouch)
	\| preparations =		\| fda_max = 200 mg/day (oral); 12 mg/day (SC); 40 mg/day (nasal spray); 44 mg/day (Onzetra)
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral, subcutaneous, intranasal
	\| onset =		\| onset = 10 minutes (SC); 15-30 minutes (nasal); 30-60 minutes (oral)
	\| duration =		\| duration = 2-4 hours; headache recurrence rate ~20-30% within 24 hours
	\| halflife =		\| halflife = 2 hours<ref name="imitrex-label">FDA Prescribing Information, Imitrex (sumatriptan succinate), GSK, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020132s029,020626s025,020080s055lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~14% (oral; substantial first-pass); ~97% (subcutaneous); ~17% (nasal)<ref name="imitrex-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data; pregnancy registry data have been broadly reassuring relative to baseline malformation rates.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US
	\| ~~intro =~~		\| mechanism = <vote slug="sumatriptan-mech-claim">Selective 5-HT1B and 5-HT1D receptor agonist. The 5-HT1B effect on cranial blood vessels produces vasoconstriction that reverses the neurogenic vasodilation of migraine; the 5-HT1D effect inhibits CGRP and other vasoactive neuropeptide release at trigeminal nerve terminals, blunting the neuroinflammatory cascade that drives migraine pain.</vote> '''Contraindicated''' in coronary artery disease, vasospastic angina (Prinzmetal), uncontrolled hypertension, history of ischemic stroke, and hemiplegic or basilar migraine. Serotonin syndrome risk with SSRIs and SNRIs has FDA labeling but the clinical incidence is debated. Should not be combined with ergot derivatives within 24 hours. '''Medicine-overuse headache''' is the major chronic-use complication, with the threshold of ≥10 days of triptan use per month<ref name="imitrex-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects =~~
	\| ~~interactions~~ = <~~pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	~~\| monitoring =~~
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

			== References ==
			<references />

	[[Category:~~Antimigraine agents~~]]		[[Category:Triptans]]
	[[Category:~~Triptans (5-HT1B/1D Agonists)~~]]		[[Category:Antimigraine medicines]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

2026-05-22T00:37:29Z

Category taxonomy ship: retag Migraine Medicines -> Antimigraine agents

← Older revision		Revision as of 00:37, 22 May 2026
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	[[Category:~~Migraine Medicines~~]]		[[Category:Antimigraine agents]]
	[[Category:Triptans (5-HT1B/1D Agonists)]]		[[Category:Triptans (5-HT1B/1D Agonists)]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:07:07Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:07, 14 May 2026
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	}}		}}


			[[Category:Migraine Medicines]]
			[[Category:Triptans (5-HT1B/1D Agonists)]]
	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:10Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:50Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:57Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Analgesics]]		[[Category:Analgesics]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Sumatriptan
+| generic            = Sumatriptan
-| brand             = Imitrex
+| brand              = Imitrex
-| classes           = Triptan, Migraine medicine
+| structure          =
-| mechanism         = 5-HT1B/1D agonist
+| classes            = Triptan, Migraine medicine
 }}
 [[Category:Analgesics]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Sumatriptan
| brand = Imitrex
| classes = Triptan, Migraine medicine
| mechanism = 5-HT1B/1D agonist
}}
[[Category:Analgesics]]