MDElliottMD: Create Tetrahydrocannabivarin (THCV) medicine stub: minor phytocannabinoid, propyl analogue of THC, biphasic CB1 activity (low-dose neutral antagonist, high-dose partial agonist), investigational interest in appetite suppression and type 2 diabetes. Cites Russo 2011 (PMID 21749363).

2026-05-19T06:22:21Z

Create Tetrahydrocannabivarin (THCV) medicine stub: minor phytocannabinoid, propyl analogue of THC, biphasic CB1 activity (low-dose neutral antagonist, high-dose partial agonist), investigational interest in appetite suppression and type 2 diabetes. Cites Russo 2011 (PMID 21749363).

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{{Stub}}
{{MedTemplate
| generic = Tetrahydrocannabivarin
| classes = Cannabinoid (minor), phytocannabinoid
| mechanism = Biphasic activity at CB1: neutral antagonist at low doses, partial agonist at high doses; partial agonist at CB2.
| intro = '''Tetrahydrocannabivarin''' (THCV, delta-9-tetrahydrocannabivarin) is a minor phytocannabinoid found in some [[Cannabis|cannabis]] chemovars, most prominently in certain African landraces. It is the propyl-side-chain analogue of [[THC]] (a pentyl side chain in THC, a propyl side chain in THCV). At low doses THCV behaves as a neutral CB1 antagonist, opposing several effects of THC; at higher doses it becomes a partial CB1 agonist. This biphasic profile is why THCV is often described both as "the appetite-suppressing cannabinoid" (at low doses, opposing the appetite-stimulating CB1 agonism of THC) and as "diet weed" in marketing contexts. Clinical interest in THCV has focused on type 2 diabetes and obesity, with several small trials reporting modest favourable effects on glycaemic control and pancreatic beta-cell function; the evidence is preliminary and no THCV-containing product is approved for any indication.<ref name="russo2011-entourage">Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. ''Br J Pharmacol''. 2011 Aug;163(7):1344-64. PMID: 21749363.</ref>
}}

[[Category:Cannabinoids]]

THCV - Revision history

MDElliottMD: Create Tetrahydrocannabivarin (THCV) medicine stub: minor phytocannabinoid, propyl analogue of THC, biphasic CB1 activity (low-dose neutral antagonist, high-dose partial agonist), investigational interest in appetite suppression and type 2 diabetes. Cites Russo 2011 (PMID 21749363).