MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:39Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Antifungals]]
			[[Category:Allylamines]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #253

2026-05-23T04:04:21Z

parser-claude batch MedTemplate pre-fill, Top 300 #253

New page

{{MedTemplate
| generic = Terbinafine
| brand = Lamisil; OTC topical Lamisil AT
| structure =
| classes = [[:Category:Antifungals|Antifungal (allylamine)]], [[:Category:Allylamines|Allylamine]]
| uses = <vote slug="onychomycosis-use">Onychomycosis (nail fungal infection)</vote>, <vote slug="tinea-pedis-use">Tinea pedis (athlete's foot)</vote>, <vote slug="tinea-corporis-use">Tinea corporis / cruris</vote>
| starting_dose = Oral: 250 mg PO once daily × 6 weeks (fingernails) or 12 weeks (toenails); topical: cream BID × 1-2 weeks
| preparations = 250 mg tablets; 1% topical cream, gel, spray; granules (pediatric)
| fda_max = 250 mg/d
| pill_id =
| routes = Oral, topical
| onset = Clinical and mycologic cure follows the full course; nail clearance over months of regrowth
| duration = 24 hours
| halflife = ~36 hours (terminal much longer due to tissue accumulation in skin/nails)<ref name="lamisil-label">FDA Prescribing Information, Lamisil (terbinafine HCl), Novartis, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020539s021lbl.pdf</ref>
| bioavailability = ~40% (oral; food does not significantly affect)<ref name="lamisil-label" />
| pregnancy = Limited data; generally avoided in pregnancy for the cosmetic indication of onychomycosis.{{citation needed}}
| legal = OTC (topical) and [[USLegal:Prescription only|Rx-only]] (oral) in US
| mechanism = <vote slug="terbinafine-mech-claim">Terbinafine inhibits fungal squalene epoxidase, blocking the early step of ergosterol biosynthesis; the resulting squalene accumulation is itself toxic, producing fungicidal (not just fungistatic) activity against dermatophytes — the basis of relatively short treatment courses for skin infections compared with azoles.</vote> CYP2D6 inhibitor — clinically relevant interaction with metoprolol, antidepressants, and other CYP2D6 substrates. Hepatotoxicity (idiosyncratic, sometimes severe) is the main systemic concern; baseline and on-treatment LFT monitoring is standard for the 12-week oral course<ref name="lamisil-label" />.
}}

== References ==
<references />

Terbinafine - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #253