Tizanidine - Revision history

MDElliottMD: parser-claude: Tizanidine MedTemplate refill, Top 300 stub upgrade

2026-05-23T06:50:45Z

parser-claude: Tizanidine MedTemplate refill, Top 300 stub upgrade

← Older revision		Revision as of 06:50, 23 May 2026
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	{{MedTemplate		{{MedTemplate
	\| generic = Tizanidine		\| generic = Tizanidine
	\| brand = Zanaflex		\| brand = Zanaflex
	\| structure =		\| structure =
	\| classes = ~~Muscle~~ relaxant		\| classes = [[:Category:Skeletal muscle relaxants\|Skeletal muscle relaxant (centrally-acting)]], [[:Category:Alpha-2 adrenergic agonists\|Alpha-2 adrenergic agonist]], [[:Category:Antispastics\|Antispastic]]
	\| ~~mechanism =~~ Alpha-2 adrenergic ~~receptor~~ agonist		\| uses = <vote slug="spasticity-multiple-sclerosis-use">Spasticity in multiple sclerosis (FDA)</vote>, <vote slug="spasticity-spinal-cord-injury-use">Spasticity in spinal cord injury (FDA)</vote>, <vote slug="spasticity-cerebral-palsy-use">Spasticity in cerebral palsy (FDA)</vote>, <vote slug="acute-musculoskeletal-pain-use">Acute musculoskeletal pain (off-label)</vote>
	\| uses =		\| starting_dose = 2 mg PO every 6-8 hours; titrate by 2-4 mg per dose every 1-4 days; maximum single dose 16 mg, maximum daily dose 36 mg
	\| starting_dose =		\| preparations = Tablets 2, 4 mg; capsules 2, 4, 6 mg ('''capsules and tablets are not bioequivalent''': capsules slower with food; tablets faster on empty stomach)
	\| preparations =		\| fda_max = 36 mg/day in three divided doses; single dose maximum 16 mg
	\| fda_max =		\| pill_id =
	\| routes =		\| routes = Oral
	\| onset =		\| onset = 30-60 minutes
	\| duration =		\| duration = 3-6 hours per dose
	\| halflife =		\| halflife = 2.5 hours (short, requires TID-QID dosing)<ref name="zanaflex-label">FDA Prescribing Information, Zanaflex (tizanidine hydrochloride), Acorda Therapeutics, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020397s029,021447s011lbl.pdf</ref>
	~~\| bioavailability =~~		\| bioavailability = ~40% (oral); food and formulation substantially alter the absorption profile<ref name="zanaflex-label" />
	~~\| pregnancy~~ =		\| pregnancy = Limited human data.{{citation needed}}
	~~\| legal~~ =		\| legal = [[USLegal:Prescription only\|Rx-only]] in US. Not a controlled substance, distinguishing it from carisoprodol among muscle-spasm options<ref name="zanaflex-label" />
	\| ~~intro =~~		\| mechanism = <vote slug="tizanidine-mech-claim">Centrally-acting α2-adrenergic receptor agonist closely related to clonidine, but with greater selectivity for spinal cord α2 receptors over peripheral α2, producing antispastic effect with somewhat less systemic hypotension and sedation than clonidine at equipotent muscle-relaxant doses. The mechanism reduces excitatory neurotransmitter release from spinal interneurons.</vote> '''CYP1A2 substrate''' with major interaction signal: fluvoxamine raises plasma exposure ~33-fold and ciprofloxacin ~10-fold, with severe hypotension reported; both combinations are '''contraindicated'''. Hepatotoxicity signal warrants baseline and periodic LFT monitoring with chronic use<ref name="zanaflex-label" />.
	~~\| pharmacokinetics~~ =
	~~\| pharmacodynamics~~ =
	\| ~~indications~~ =
	\| ~~dosing~~ =
	\| ~~effects~~ =
	\| ~~interactions~~ = <~~pharmaInteractions~~/>
	~~\| pregnancy_details =~~
	\| monitoring =
	~~\| counseling =~~
	~~\| anecdotes =~~
	~~\| seealso =~~
	~~\| references~~ =
	}}		}}

	[[Category:~~Muscle~~ relaxants]]		== References ==
			<references />

			[[Category:Skeletal muscle relaxants]]
			[[Category:Alpha-2 adrenergic agonists]]
			[[Category:Antispastics]]

MDElliottMD: Tier 1 taxonomy consolidation: removed redundant Category:Muscle_Relaxants (canonical already present)

2026-05-21T17:02:01Z

Tier 1 taxonomy consolidation: removed redundant Category:Muscle_Relaxants (canonical already present)

← Older revision		Revision as of 17:02, 21 May 2026
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	[[Category:Muscle relaxants]]		[[Category:Muscle relaxants]]
	~~[[Category:Muscle_Relaxants]]~~

MDElliottMD: Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

2026-05-19T18:00:19Z

Dedupe migration per interface-claude 2026-05-20: Muscle Relaxants (CNS-acting) merged into canonical Muscle relaxants. Member retagged.

← Older revision		Revision as of 18:00, 19 May 2026
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	}}		}}

			[[Category:Muscle relaxants]]
	[[Category:Muscle ~~Relaxants (CNS-acting)~~]]
	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MediaWiki default: Assign pharmacological categories from List_of_CNS-active_medicines

2026-05-14T15:07:07Z

Assign pharmacological categories from List_of_CNS-active_medicines

← Older revision		Revision as of 15:07, 14 May 2026
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	}}		}}


			[[Category:Muscle Relaxants (CNS-acting)]]
	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MDElliottMD: Pharmacopedia: add

2026-05-14T03:31:11Z

Pharmacopedia: add <pharmaInteractions/>

← Older revision		Revision as of 03:31, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	\| interactions =		\| interactions = <pharmaInteractions/>
	\| pregnancy_details =		\| pregnancy_details =
	\| monitoring =		\| monitoring =

MDElliottMD: Pharmacopedia: remove contraindications parameter

2026-05-14T02:40:52Z

Pharmacopedia: remove contraindications parameter

← Older revision		Revision as of 02:40, 14 May 2026
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	\| dosing =		\| dosing =
	\| effects =		\| effects =
	~~\| contraindications =~~
	\| interactions =		\| interactions =
	\| pregnancy_details =		\| pregnancy_details =

MDElliottMD: Added empty fda_max parameter to MedTemplate call

2026-05-13T02:32:56Z

Added empty fda_max parameter to MedTemplate call

← Older revision		Revision as of 02:32, 13 May 2026
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	\| starting_dose =		\| starting_dose =
	\| preparations =		\| preparations =
			\| fda_max =
	\| routes =		\| routes =
	\| onset =		\| onset =
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	[[Category:Muscle_Relaxants]]		[[Category:Muscle_Relaxants]]

MDElliottMD: Expand stub to full MedTemplate parameter set

2026-05-13T01:00:00Z

Expand stub to full MedTemplate parameter set

@@ Line 1: / Line 1: @@
 {{MedTemplate
-| generic           = Tizanidine
+| generic            = Tizanidine
-| brand             = Zanaflex
+| brand              = Zanaflex
-| classes           = Muscle relaxant
+| structure          =
-| mechanism         = Alpha-2 adrenergic receptor agonist
+| classes            = Muscle relaxant
 }}
 [[Category:Muscle_Relaxants]]

MDElliottMD: Auto-created stub

2026-05-13T00:00:00Z

Auto-created stub

New page

{{MedTemplate
| generic = Tizanidine
| brand = Zanaflex
| classes = Muscle relaxant
| mechanism = Alpha-2 adrenergic receptor agonist
}}
[[Category:Muscle_Relaxants]]