MDElliottMD: home-claude category backfill (parser-claude gap closure)

2026-05-23T10:43:43Z

home-claude category backfill (parser-claude gap closure)

← Older revision		Revision as of 10:43, 23 May 2026
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	== References ==		== References ==
	<references />		<references />
			[[Category:Vitamins]]
			[[Category:Fat-soluble vitamins]]
			[[Category:Antioxidants]]

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #290

2026-05-23T04:19:16Z

parser-claude batch MedTemplate pre-fill, Top 300 #290

New page

{{MedTemplate
| generic = Vitamin E (α-tocopherol; mixed natural and synthetic forms)
| brand = Generic; many OTC formulations
| structure =
| classes = [[:Category:Vitamins|Vitamin]], [[:Category:Fat-soluble_vitamins|Fat-soluble vitamin]], [[:Category:Antioxidants|Antioxidant]]
| uses = <vote slug="vitamin-e-deficiency-use">Vitamin E deficiency (often in fat malabsorption: cystic fibrosis, cholestasis, abetalipoproteinemia)</vote>, <vote slug="nash-mash-use">Nonalcoholic steatohepatitis in non-diabetic adults (high-dose, evidence-based)</vote>, <vote slug="amd-use">Age-related macular degeneration (AREDS combination)</vote>
| starting_dose = Replacement: 15-30 mg (22.5-45 IU) daily; NASH: 800 IU daily; AREDS-2: 400 IU daily (in combination formula)
| preparations = 100, 200, 400 IU softgels and capsules; many proprietary OTC blends; combined formulations (AREDS-2)
| fda_max = UL 1000 mg (~1500 IU natural)/d in adults; routinely exceeded in older AREDS-1 trials
| pill_id =
| routes = Oral
| onset = Days to weeks for tissue saturation
| duration = Weeks (fat-soluble)
| halflife = ~3-4 days plasma; adipose tissue stores last months
| bioavailability = High with fat-containing meal; reduced in malabsorption
| pregnancy = Safe at replacement doses; high-dose use generally avoided.{{citation needed}}
| legal = OTC in US
| mechanism = <vote slug="vitamin-e-mech-claim">α-Tocopherol is the principal lipid-soluble antioxidant in cell membranes, scavenging peroxyl radicals to terminate lipid peroxidation chain reactions; the regenerated tocopheroxyl radical is reduced back to tocopherol by ascorbate and glutathione, integrating the major non-enzymatic antioxidant defenses.</vote> Beyond antioxidant function, modulates protein kinase C signaling. '''Bleeding risk with high-dose use''' (vitamin K antagonism in vitamin K-deficient states; possible platelet effects independent of vitamin K); caution with warfarin or in surgical patients. Some meta-analyses of high-dose supplementation (>400 IU) suggest increased all-cause mortality, tempering routine use outside specific indications.
}}

== References ==
<references />

Vitamin E - Revision history

MDElliottMD: home-claude category backfill (parser-claude gap closure)

MDElliottMD: parser-claude batch MedTemplate pre-fill, Top 300 #290