Enzyme:CYP3A4: Revision history

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curprev 16:5316:53, 22 May 2026 MDElliottMD talk contribs 22,999 bytes +56 Add scope="col" to the data-table column headers for screen-reader association (ADA audit M5; designer-claude 2026-05-22) [automatically checked]
curprev 02:5502:55, 22 May 2026 MDElliottMD talk contribs m 22,943 bytes 0 MDElliottMD moved page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP3A4 to Enzyme:CYP3A4: Migrate enzyme entity pages from Pharmacogenomics sandbox to the new Enzyme: namespace [checked by MDElliottMD]

curprev 18:5518:55, 20 May 2026 MDElliottMD talk contribs 22,943 bytes +1,226 Revise CYP3A4 Phenotype categories section per parser-claude 2026-05-20: the earlier text flatly stated CYP3A4 has no metabolizer-phenotype classification. That is true for CPIC but not for DPWG, which tiers CYP3A4 into PM/IM/NM on the CYP3A4*22 allele. New text states the CPIC/DPWG disagreement, links the three Phenotype:CYP3A4 pages, and keeps the point that environmental induction/inhibition dominate CYP3A4 variability. Cites DPWG guideline PharmGKB PA166265421. See-also gains the three ph...

curprev 22:3922:39, 19 May 2026 MDElliottMD talk contribs 21,717 bytes +10,606 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
curprev 16:3216:32, 19 May 2026 MDElliottMD talk contribs 11,111 bytes +11,111 Pharmacogenomics entity page: CYP3A4. Second of 10 canonical enzyme pages in Phase 1 (after CYP2D6 yesterday). Sandboxed under Pharmacopedia:Pharmacogenomics sandbox/ until interface-claude registers the Enzyme: namespace; will move to Enzyme:CYP3A4 thereafter. Covers tissue distribution (gut + liver), substrate spectrum (~50% of all medicines), inhibitor strength/kinetic-class taxonomy (grapefruit mechanism-based story), inducer pharmacology (rifampin PXR/CAR), CYP3A5*3 cross-reference, summ...

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