1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Amitriptyline (hydrochloride) |
| brand | String | Elavil (US brand discontinued; generic widely available), Endep, Tryptizol |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Tricyclic antidepressants|Tricyclic antidepressant (TCA)]] • [[:Category:Antidepressants|Antidepressant]] • [[:Category:Migraine prophylactics|Migraine prophylactic]] • [[:Category:Neuropathic pain medicines|Neuropathic pain medicine]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' |
| starting_dose | String | Depression (rarely used now): 25-75 mg PO at bedtime, titrate to 150 mg/day. Neuropathic pain / migraine prophylaxis: 10-25 mg at bedtime, titrate by 10-25 mg weekly to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions apply) |
| preparations | String | Tablets 10, 25, 50, 75, 100, 150 mg |
| fda_max | String | 300 mg/day (historical hospitalized inpatient depression); 150 mg/day outpatient typical ceiling |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Sleep effect from first dose; analgesic and migraine-prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks |
| duration | String | 24 hours (HS dosing) |
| halflife | String | Amitriptyline 10-50 hours (highly variable); nortriptyline active metabolite 18-44 hours'"`UNIQ--ref-00000026-QINU`"' |
| bioavailability | String | ~50% (oral)'"`UNIQ--ref-00000027-QINU`"' |
| pregnancy | String | Older agent with substantial use experience; observational signals not clearly causal.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"' |
