'"`UNIQ--vote-00000073-QINU`"' The long half-life gives smooth, once-daily BP control with low rebound. CYP3A4 substrate; pedal edema is the characteristic, dose-related, non-fluid-overload side effect'"`UNIQ--ref-00000074-QINU`"'.
BP effect within 24 hours; full effect at 1-2 weeks (long half-life)
duration
String
24 hours
halflife
String
30-50 hours'"`UNIQ--ref-00000078-QINU`"'
bioavailability
String
64-90% (oral; not affected by food)'"`UNIQ--ref-00000079-QINU`"'
pregnancy
String
Limited data; case series and registries suggest no major teratogenicity but other antihypertensives (labetalol, nifedipine) are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
