1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Bupropion |
| brand | String | Wellbutrin (IR, SR, XL), Zyban (smoking cessation), Aplenzin (hydrobromide salt), Forfivo XL |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:NDRIs|Norepinephrine-dopamine reuptake inhibitor (NDRI)]] • [[:Category:Antidepressants|Antidepressant]] • [[:Category:Smoking cessation medicines|Smoking cessation medicine]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"' |
| starting_dose | String | SR 150 mg PO once daily for 3 days, then 150 mg BID. XL 150 mg PO once daily for 4 days, then 300 mg once daily. Zyban (smoking cessation) 150 mg daily for 3 days, then 150 mg BID |
| preparations | String | SR tablets 100, 150, 200 mg; XL tablets 150, 300 mg; IR tablets 75, 100 mg (less common); Aplenzin (bupropion hydrobromide) 174, 348, 522 mg |
| fda_max | String | 450 mg/day; doses above this raise seizure risk steeply |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | 1-2 weeks for antidepressant effect; smoking-cessation effect builds over the first 1-2 weeks |
| duration | String | SR ~12 hours; XL 24 hours |
| halflife | String | Bupropion ~21 hours; hydroxybupropion (active metabolite) ~20-37 hours'"`UNIQ--ref-00000023-QINU`"' |
| bioavailability | String | ~5-20% (extensive first-pass), highly variable between individuals'"`UNIQ--ref-00000024-QINU`"' |
| pregnancy | String | Limited human data; some animal cardiac signal not clearly replicated in human cohort studies; observational signals inconclusive.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults. Not controlled'"`UNIQ--ref-00000025-QINU`"' |
