1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Cyclosporine (ciclosporin) |
| brand | String | Sandimmune, Neoral (modified microemulsion, increased bioavailability), Gengraf, Restasis (ophthalmic) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Calcineurin_inhibitors|Calcineurin inhibitor]] • [[:Category:Immunosuppressants|Immunosuppressant]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-00000A8C-QINU`"', '"`UNIQ--vote-00000A8D-QINU`"', '"`UNIQ--vote-00000A8E-QINU`"', '"`UNIQ--vote-00000A8F-QINU`"', '"`UNIQ--vote-00000A90-QINU`"' |
| starting_dose | String | Transplant: 5-10 mg/kg/d divided BID, titrated to trough levels (typically 100-300 ng/mL depending on regimen and post-transplant interval); ophthalmic Restasis 0.05% one drop BID |
| preparations | String | Sandimmune 25, 100 mg capsules; Neoral 25, 100 mg modified soft gel; 100 mg/mL oral solution; 50 mg/mL IV; Restasis 0.05% ophthalmic emulsion |
| fda_max | String | Transplant: regimen-specific |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IV • ophthalmic |
| onset | String | Days for immunosuppressive effect |
| duration | String | Dosing-frequency dependent |
| halflife | String | ~8-27 hours (highly variable across the population)'"`UNIQ--ref-00000A91-QINU`"' |
| bioavailability | String | Sandimmune: highly variable (~30%); Neoral microemulsion: ~50%, less variable; '''Sandimmune and Neoral are NOT bioequivalent and not interchangeable''''"`UNIQ--ref-00000A92-QINU`"' |
| pregnancy | String | Used in transplant pregnancy when continued immunosuppression is required; reassuring data overall but careful monitoring needed.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warning''' for risk of malignancy and serious infection; nephrotoxicity, hypertension, and immunosuppression-associated complications'"`UNIQ--ref-00000A93-QINU`"' |
