'"`UNIQ--vote-0000001D-QINU`"' CYP2C19 + CYP3A4 metabolism, with CPIC PGx guidance: poor CYP2C19 metabolizers have ~3-fold higher exposure and benefit from a lower starting dose; ultrarapid metabolizers may have inadequate response'"`UNIQ--ref-0000001E-QINU`"'.
10 mg PO once daily; titrate to 20 mg/day after 1-2 weeks if needed
preparations
String
Tablets 5, 10, 20 mg; oral solution 1 mg/mL
fda_max
String
20 mg/day (adult); 10 mg/day in elderly and in hepatic impairment
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
Antidepressant effect emerges over 1-2 weeks; full clinical effect 4-6 weeks
duration
String
24 hours (once-daily dosing)
halflife
String
27-32 hours'"`UNIQ--ref-00000026-QINU`"'
bioavailability
String
~80% (oral)'"`UNIQ--ref-00000027-QINU`"'
pregnancy
String
legal
String
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"'
