1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Gabapentin |
| brand | String | Neurontin (IR), Gralise (ER), Horizant (gabapentin enacarbil ER) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Gabapentinoids|Gabapentinoid]] • [[:Category:Anticonvulsants|Anticonvulsant]] • [[:Category:Neuropathic pain medicines|Neuropathic pain medicine]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"', '"`UNIQ--vote-00000026-QINU`"', '"`UNIQ--vote-00000027-QINU`"', '"`UNIQ--vote-00000028-QINU`"' |
| starting_dose | String | 300 mg PO at bedtime night 1, 300 mg BID day 2, 300 mg TID day 3; titrate to clinical effect, commonly 1800-3600 mg/day divided TID |
| preparations | String | Capsules 100, 300, 400 mg; tablets 600, 800 mg; oral solution 250 mg/5 mL; Gralise ER tablets 300, 600 mg (once-daily); Horizant ER tablets 300, 600 mg (gabapentin enacarbil, an inactive parent compound metabolized to gabapentin in vivo) |
| fda_max | String | 3600 mg/day; off-label doses higher are common but bioavailability saturates well below this |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | 1-2 weeks for neuropathic pain and anxiolytic effect; anticonvulsant effect at therapeutic plasma level |
| duration | String | TID dosing for IR; once-daily for ER formulations |
| halflife | String | 5-7 hours'"`UNIQ--ref-00000029-QINU`"' |
| bioavailability | String | '''Saturable''' via the LAT-1 amino-acid transporter, producing nonlinear pharmacokinetics: ~60% at 300 mg single dose, falling to ~35% at 1200 mg single dose'"`UNIQ--ref-0000002A-QINU`"' |
| pregnancy | String | Limited human data; some signal for cardiac malformations and developmental delay but confounded by maternal disease and polytherapy.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | |
