'"`UNIQ--vote-000002D7-QINU`"' Hypoglycemia is the central risk, especially in elderly and renally impaired patients (glipizide has shorter half-life than glyburide, which is one reason it is preferred in older adults). CYP2C9 substrate; weight gain typical.
uses
String
'"`UNIQ--vote-000002D8-QINU`"'
starting_dose
String
5 mg PO once daily, 30 minutes before breakfast; XL: 5 mg with breakfast
40 mg/d (IR; doses >15 mg given as divided BID); 20 mg/d (XL)
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
Within 30 minutes (IR)
duration
String
~12-24 hours
halflife
String
2-5 hours'"`UNIQ--ref-000002D9-QINU`"'
bioavailability
String
~100% (oral; food delays absorption, hence pre-meal dosing for IR)'"`UNIQ--ref-000002DA-QINU`"'
pregnancy
String
Avoid; switch to insulin. Hypoglycemia in newborn reported.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
