Constipation: 15-30 mL PO daily (titrate to 1-2 soft stools/day); hepatic encephalopathy: 20-30 g (30-45 mL) PO/PR every 1-2 hours acutely until soft stools, then BID-QID to target 2-3 soft stools/day
preparations
String
10 g/15 mL solution (Constulose); 10 g, 20 g powder packets (Kristalose)
fda_max
String
Indication-specific; HE may require high-volume dosing
pill_id
Text
routes
List of String, delimiter: ,
Oral • rectal (enema • especially in acute HE)
onset
String
Constipation: 24-48 hours; HE: ammonia reduction within hours of stool production
duration
String
Hours
halflife
String
Not meaningfully described — lactulose is not significantly absorbed
bioavailability
String
<3% systemic absorption (the basis of the safety and mechanism)'"`UNIQ--ref-00000F5E-QINU`"'
pregnancy
String
Generally considered safe (minimal systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
