1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Levothyroxine |
| brand | String | Synthroid, Levoxyl, Tirosint, Unithroid, Euthyrox |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Thyroid_hormones|Thyroid hormone]] • [[:Category:Hormone_replacement|Hormone replacement]] |
| mechanism | String | Synthetic T4 (thyroxine); peripherally deiodinated to T3 (triiodothyronine), the active hormone. '"`UNIQ--vote-00000031-QINU`"' Narrow therapeutic index; brand-to-generic switches can shift TSH and require re-titration'"`UNIQ--ref-00000032-QINU`"'. |
| uses | String | '"`UNIQ--vote-00000033-QINU`"', '"`UNIQ--vote-00000034-QINU`"', '"`UNIQ--vote-00000035-QINU`"' |
| starting_dose | String | 1.6 mcg/kg/d in young healthy adults; 25-50 mcg/d in elderly or cardiac disease, titrated by TSH at 6-8 weeks |
| preparations | String | 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200, 300 mcg tablets; oral capsule and IV/IM also available |
| fda_max | String | No fixed maximum; titrated to TSH target |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IV |
| onset | String | TSH normalization 4-8 weeks; symptomatic improvement weeks to months |
| duration | String | Steady-state at 4-6 weeks |
| halflife | String | ~7 days (euthyroid); longer in hypothyroidism (~9-10 days), shorter in hyperthyroidism'"`UNIQ--ref-00000036-QINU`"' |
| bioavailability | String | 40-80% (oral); reduced by food, calcium, iron, PPIs, fiber; take fasting with water'"`UNIQ--ref-00000037-QINU`"' |
| pregnancy | String | First-line in pregnancy; dose typically increased 25-30% due to estrogen-driven rise in TBG and fetal demand. Lactation safe at physiologic doses.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |
