4 mg PO initially, then 2 mg after each loose stool, '''not to exceed 16 mg/d''' (8 mg OTC); chronic-use lower
preparations
String
2 mg capsules and tablets; 1 mg/5 mL oral solution; combined with simethicone (Imodium Multi-Symptom)
fda_max
String
16 mg/d (8 mg/d OTC)
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
30-60 minutes
duration
String
8-12 hours
halflife
String
~9-14 hours'"`UNIQ--ref-00000FD2-QINU`"'
bioavailability
String
~0.3% (oral; extensive first-pass via CYP3A4 and P-glycoprotein-mediated efflux at the intestinal and blood-brain barriers limit systemic and CNS exposure at therapeutic doses)'"`UNIQ--ref-00000FD3-QINU`"'
pregnancy
String
Generally considered acceptable when needed.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
