20 mg PO once daily with the evening meal; titrate to 40-80 mg/d
preparations
String
10, 20, 40 mg tablets; 20, 40, 60 mg ER tablets
fda_max
String
80 mg/d (40 mg/d if combined with diltiazem, verapamil, danazol; lower limits with various interactions)
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
LDL lowering at 2 weeks, max by 4 weeks
duration
String
24 hours
halflife
String
~2-4 hours (parent and active β-hydroxy acid metabolite); pharmacodynamic effect 24 hours via target turnover'"`UNIQ--ref-00000807-QINU`"'
bioavailability
String
<5% (extensive hepatic first-pass; food enhances absorption of IR, hence the evening-meal dosing)'"`UNIQ--ref-00000808-QINU`"'
pregnancy
String
Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
