1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Melatonin (N-acetyl-5-methoxytryptamine) |
| brand | String | Multiple OTC dietary supplement formulations |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Melatonin receptor agonists|Melatonin receptor agonist]] • [[:Category:Sleep aids|Sleep aid]] • [[:Category:Chronobiotics|Chronobiotic (circadian phase regulator)]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"' |
| starting_dose | String | 0.5-3 mg PO 30-60 minutes before bedtime. Some patients respond to micro-doses (0.3 mg) without additional benefit at higher doses. For circadian phase shifting, timing relative to dim-light melatonin onset matters more than absolute dose |
| preparations | String | OTC tablets, sublingual tablets, gummies, liquid, extended-release tablets and capsules; common strengths 0.5, 1, 3, 5, 10 mg |
| fda_max | String | Not formally established (dietary supplement); doses above ~3-5 mg show no additional efficacy but increase next-day sedation risk |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • sublingual |
| onset | String | 30-60 minutes (immediate-release oral) |
| duration | String | 3-4 hours |
| halflife | String | 30-50 minutes (short)'"`UNIQ--ref-00000021-QINU`"' |
| bioavailability | String | ~15% (oral; highly variable due to extensive and variable first-pass metabolism)'"`UNIQ--ref-00000022-QINU`"' |
| pregnancy | String | Limited human data; endogenous hormone, but supplemental pharmacological doses are not well characterized in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Over-the-counter|OTC]] dietary supplement in the US ('''not FDA-regulated as a medicine'''; multiple studies show OTC products contain 50-470% of labeled melatonin content); [[USLegal:Prescription only|Rx-only]] in the EU and UK |
