1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Metformin |
| brand | String | Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Biguanides|Biguanide]] • [[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] |
| mechanism | String | '"`UNIQ--vote-00000013-QINU`"' Does not stimulate insulin secretion; minimal hypoglycemia risk as monotherapy. Cleared renally unchanged; dose-adjust by eGFR'"`UNIQ--ref-00000014-QINU`"'. Rare lactic acidosis primarily in renal failure or acute illness. |
| uses | String | '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"', '"`UNIQ--vote-00000017-QINU`"' |
| starting_dose | String | 500 mg PO once or twice daily with meals; titrate weekly to limit GI effects |
| preparations | String | 500 mg, 850 mg, 1000 mg IR tablets; 500 mg, 750 mg, 1000 mg ER tablets; 500 mg/5 mL oral solution |
| fda_max | String | 2550 mg/d (IR); 2000 mg/d (ER) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Glucose lowering within days; HbA1c effect at 8-12 weeks |
| duration | String | ~12 hours (IR); 24 hours (ER) |
| halflife | String | 6.2 hours (plasma); ~17 hours in erythrocytes'"`UNIQ--ref-00000018-QINU`"' |
| bioavailability | String | 50-60% (oral; decreased with food, but food given anyway for GI tolerance)'"`UNIQ--ref-00000019-QINU`"' |
| pregnancy | String | Generally considered safe; widely used in PCOS and gestational diabetes; placental transfer occurs.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |
