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Field Field type Value generic String Methimazole (thiamazole) brand String Tapazole; outside US Mercazole structure File classes List of String , delimiter: , [[:Category:Antithyroid_agents|Antithyroid agent]] • [[:Category:Thionamides|Thionamide]] mechanism String '"`UNIQ--vote-00000ECD-QINU`"' Agranulocytosis is the most-feared adverse effect (~0.3%, usually first 90 days of treatment; warn patients to seek urgent CBC for fever or severe sore throat). Hepatotoxicity is class-recognized but more often associated with PTU'"`UNIQ--ref-00000ECE-QINU`"'. uses String '"`UNIQ--vote-00000ECF-QINU`"', '"`UNIQ--vote-00000ED0-QINU`"', '"`UNIQ--vote-00000ED1-QINU`"', '"`UNIQ--vote-00000ED2-QINU`"' starting_dose String 10-40 mg PO daily depending on hyperthyroidism severity; titrate by clinical and biochemical response (target TSH/free T4) preparations String 5, 10 mg tablets fda_max String 60 mg/d typical pill_id Text routes List of String , delimiter: , Oral onset String Biochemical improvement within 2-4 weeks; full euthyroid state 6-12 weeks duration String 24 hours halflife String ~4-6 hours (plasma); intrathyroidal accumulation gives a much longer functional duration'"`UNIQ--ref-00000ED3-QINU`"' bioavailability String ~93% (oral)'"`UNIQ--ref-00000ED4-QINU`"' pregnancy String legal String [[USLegal:Prescription only|Rx-only]] in US
