1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Methotrexate |
| brand | String | Trexall, Otrexup, Rasuvo, Xatmep, Rheumatrex (discontinued) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Antifolates|Antifolate]] • [[:Category:DMARDs|DMARD]] • [[:Category:Antineoplastics|Antineoplastic]] • [[:Category:Immunosuppressants|Immunosuppressant]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-000007C1-QINU`"', '"`UNIQ--vote-000007C2-QINU`"', '"`UNIQ--vote-000007C3-QINU`"', '"`UNIQ--vote-000007C4-QINU`"', '"`UNIQ--vote-000007C5-QINU`"', '"`UNIQ--vote-000007C6-QINU`"', '"`UNIQ--vote-000007C7-QINU`"' |
| starting_dose | String | Rheumatologic: 7.5-15 mg PO or SC '''once weekly''' (not daily — daily dosing is a recognized fatal error); folic acid 1 mg PO daily on non-MTX days; oncology dosing is far higher and indication-specific |
| preparations | String | 2.5 mg tablets; 10-50 mg/mL injection; pre-filled subcutaneous autoinjectors (Otrexup, Rasuvo); 2.5 mg/mL oral solution (Xatmep) |
| fda_max | String | Rheumatologic ~25 mg/week; oncology indication-specific |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • subcutaneous • intramuscular • IV • intrathecal |
| onset | String | Rheumatologic effect at 4-8 weeks; ectopic resolution over 2-3 weeks |
| duration | String | Once-weekly dosing in rheumatology |
| halflife | String | 3-10 hours (low dose); 8-15 hours (high dose); much longer in third-space accumulation (pleural effusion, ascites)'"`UNIQ--ref-000007C8-QINU`"' |
| bioavailability | String | 60-70% PO at low doses; saturable at high doses (parenteral routes preferred above 15-25 mg/week)'"`UNIQ--ref-000007C9-QINU`"' |
| pregnancy | String | '''Contraindicated in pregnancy''' (Category X); abortifacient and teratogenic. Discontinuation 3-6 months before conception is standard.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |
