[[:Category:NSAIDs|Non-steroidal anti-inflammatory drug (NSAID)]] • [[:Category:Acetic_acid_derivatives|Acetic acid derivative]]
mechanism
String
'"`UNIQ--vote-000011F4-QINU`"' Like all NSAIDs, raises CV thrombotic risk modestly (FDA 2014/2015 advisory) and produces GI, renal, hypertensive, and platelet-inhibitory effects characteristic of the class'"`UNIQ--ref-000011F5-QINU`"'.
1000 mg PO once daily; 500-2000 mg/d in single or divided doses
preparations
String
500, 750 mg tablets
fda_max
String
2000 mg/d
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
Analgesia within hours; anti-inflammatory effect over days
duration
String
24 hours
halflife
String
~24 hours (6-methoxy-2-naphthylacetic acid, the active metabolite)'"`UNIQ--ref-000011F9-QINU`"'
bioavailability
String
~38% (oral; non-acidic prodrug improves GI tolerability over many other NSAIDs)'"`UNIQ--ref-000011FA-QINU`"'
pregnancy
String
Avoid after 20 weeks (NSAID-class FDA 2020 advisory on fetal renal injury and oligohydramnios with second/third-trimester use).<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
legal
String
[[USLegal:Prescription only|Rx-only]] in US. Carries the NSAID-class '''Boxed Warning''' for cardiovascular thrombotic events and serious GI bleeding'"`UNIQ--ref-000011FB-QINU`"'
