1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Nortriptyline (hydrochloride) |
| brand | String | Pamelor (US brand discontinued; generic widely available), Aventyl |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Tricyclic antidepressants|Tricyclic antidepressant (TCA • secondary amine)]] • [[:Category:Antidepressants|Antidepressant]] • [[:Category:Neuropathic pain medicines|Neuropathic pain medicine]] • [[:Category:Migraine prophylactics|Migraine prophylactic]] |
| mechanism | String | '"`UNIQ--vote-00000019-QINU`"' Therapeutic plasma-level monitoring is standard practice for TCAs given the narrow therapeutic index and the established plasma-level-efficacy correlation. CYP2D6 substrate; CPIC PGx guidance applies for dose individualization'"`UNIQ--ref-0000001A-QINU`"'. |
| uses | String | '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' |
| starting_dose | String | Depression: 25 mg PO TID-QID or 75 mg at bedtime, titrate to 75-150 mg/day. Neuropathic pain: 10-25 mg at bedtime, titrate to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions, though less than amitriptyline) |
| preparations | String | Capsules 10, 25, 50, 75 mg; oral solution 10 mg/5 mL |
| fda_max | String | 150 mg/day; therapeutic plasma-level monitoring recommended (target 50-150 ng/mL window) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Pain and migraine prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks |
| duration | String | 24 hours (HS dosing) |
| halflife | String | 18-44 hours'"`UNIQ--ref-00000020-QINU`"' |
| bioavailability | String | ~50% (oral)'"`UNIQ--ref-00000021-QINU`"' |
| pregnancy | String | TCA class signal; limited human data specific to nortriptyline.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"' |
