1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Paroxetine (HCl; mesylate as Pexeva) |
| brand | String | Paxil (IR), Paxil CR (controlled-release), Brisdelle (low-dose for menopausal vasomotor symptoms), Pexeva (paroxetine mesylate) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:SSRIs|Selective serotonin reuptake inhibitor (SSRI)]] • [[:Category:Antidepressants|Antidepressant]] • [[:Category:Anxiolytics|Anxiolytic]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"', '"`UNIQ--vote-00000026-QINU`"', '"`UNIQ--vote-00000027-QINU`"', '"`UNIQ--vote-00000028-QINU`"', '"`UNIQ--vote-00000029-QINU`"', '"`UNIQ--vote-0000002A-QINU`"' |
| starting_dose | String | MDD/GAD: 20 mg PO once daily. Panic disorder: 10 mg titrating to 40 mg. OCD: 20 mg titrating to 40-60 mg. CR: 25 mg/day. Brisdelle: 7.5 mg at bedtime for hot flashes |
| preparations | String | IR tablets 10, 20, 30, 40 mg; CR tablets 12.5, 25, 37.5 mg; oral suspension 10 mg/5 mL; Brisdelle capsules 7.5 mg |
| fda_max | String | 50 mg/day (IR); 62.5 mg/day (CR); 60 mg/day (OCD) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Antidepressant effect emerges over 1-2 weeks |
| duration | String | 24 hours (once-daily dosing) |
| halflife | String | ~21 hours (with nonlinear pharmacokinetics from CYP2D6 autoinhibition)'"`UNIQ--ref-0000002B-QINU`"' |
| bioavailability | String | Highly variable due to saturable first-pass metabolism'"`UNIQ--ref-0000002C-QINU`"' |
| pregnancy | String | '''Among the least preferred SSRIs in pregnancy.''' Observational signal for cardiac malformations (atrial and ventricular septal defects) with first-trimester exposure, and the most severe neonatal adaptation syndrome of any SSRI with third-trimester exposure'"`UNIQ--ref-0000002D-QINU`"' |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-0000002E-QINU`"' |
