Selective inverse agonist at 5HT2A receptors with weaker activity at 5HT2C. Has no significant dopamine D2 affinity, unique among approved antipsychotics. Inverse agonism (rather than antagonism) reduces constitutive 5HT2A receptor activity below baseline.
uses
String
Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression.
starting_dose
String
34 mg PO once daily
preparations
String
10 mg, 34 mg capsules/tablets
fda_max
String
34 mg/d
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
Benefit over weeks of dosing
duration
String
Daily dosing
halflife
String
~57 hours (parent), ~200 h (active metabolite)
bioavailability
String
Not characterized; oral dosing once daily
pregnancy
String
Limited data; avoid
legal
String
Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)
