Page values for "Sodium Oxybate"

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"Medicines" values

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Field	Field type	Value
generic	`String`	Sodium Oxybate
brand	`String`	Xyrem; Xywav (lower-sodium formulation with Ca/Mg/K salts)
structure	`File`
classes	List of `String`, delimiter: `,`	GABAB Agonist; Endogenous GHB receptor agonist
mechanism	`String`	Agonist at the metabotropic GABAB receptor and the endogenous γ-hydroxybutyrate (GHB) receptor. Produces deep sleep with increased slow-wave architecture, suppression of REM intrusion, and cataplexy reduction.
uses	`String`	'"`UNIQ--vote-00000717-QINU`"', '"`UNIQ--vote-00000718-QINU`"', '"`UNIQ--vote-00000719-QINU`"'
starting_dose	`String`	2.25 g at bedtime + 2.25 g 2.5–4 h later; titrate weekly to 6–9 g/night total
preparations	`String`	0.5 g/mL oral solution
fda_max	`String`	9 g/night
pill_id	`Text`
routes	List of `String`, delimiter: `,`	Oral (must be taken in bed; effects within minutes)
onset	`String`	15–30 min (fasting)
duration	`String`	~3 h per dose (twice-nightly schedule required)
halflife	`String`	30–60 min
bioavailability	`String`	~25% (high first-pass)
pregnancy	`String`	Category C
legal	`String`	Schedule III; REMS-restricted (Schedule I if outside the pharmaceutical channel, same molecule as illicit GHB)