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Field Field type Value generic String Valsartan brand String Diovan; Entresto (in fixed-dose combination with sacubitril) structure File classes List of String , delimiter: , [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] • [[:Category:Antihypertensives|Antihypertensive]] mechanism String '"`UNIQ--vote-000004C8-QINU`"' Largely hepatically cleared (~80% biliary); no active metabolite. Sacubitril-valsartan (Entresto) combines an ARB with neprilysin inhibition for HFrEF and was a notable advance over the ARB-alone trial (PARADIGM-HF, 2014)'"`UNIQ--ref-000004C9-QINU`"'. uses String '"`UNIQ--vote-000004CA-QINU`"', '"`UNIQ--vote-000004CB-QINU`"', '"`UNIQ--vote-000004CC-QINU`"' starting_dose String 80-160 mg PO once daily (40 mg BID in HFrEF, titrating up to 160 mg BID) preparations String 40, 80, 160, 320 mg tablets; oral suspension fda_max String 320 mg/d (hypertension); 320 mg/d (HF) pill_id Text routes List of String , delimiter: , Oral onset String BP effect 2 hours; max at 4-6 weeks duration String 24 hours halflife String ~6 hours'"`UNIQ--ref-000004CD-QINU`"' bioavailability String ~25% (oral; food reduces absorption ~40%)'"`UNIQ--ref-000004CE-QINU`"' pregnancy String '''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-000004CF-QINU`"' legal String [[USLegal:Prescription only|Rx-only]] in US
