Selective NET inhibitor (no significant DAT activity, distinguishes from amphetamine/methylphenidate). Also: 5HT1A receptor partial agonism, 5HT2B and 5HT7 receptor antagonism. The serotonergic actions may underlie better tolerability and possibly different efficacy spectrum than atomoxetine.
uses
String
ADHD in children (6+), adolescents, and adults (FDA-approved 2021 for pediatric, 2022 for adult)
starting_dose
String
Pediatric 6-11: 100 mg PO daily, titrate weekly to max 400 mg. Adolescent 12-17: 200 mg, max 400 mg. Adult: 200 mg, max 600 mg.
preparations
String
100 mg, 150 mg, 200 mg extended-release capsules (can be sprinkled on food)
fda_max
String
400 mg/d (pediatric); 600 mg/d (adult)
pill_id
Text
routes
List of String, delimiter: ,
Oral
onset
String
ADHD symptom improvement reported within 1-2 weeks (faster than atomoxetine which takes 4-6 weeks)
duration
String
Daily dosing
halflife
String
~7 hours
bioavailability
String
Adequate oral bioavailability with extended-release formulation
pregnancy
String
Limited data
legal
String
Rx, '''not a controlled substance''' (no DEA scheduling)
