Page values for "Brexanolone"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | |
| brand | String | Zulresso |
| structure | File | |
| classes | List of String, delimiter: , | Neuroactive steroid • GABA-A positive allosteric modulator |
| mechanism | String | |
| uses | String | Postpartum depression (PPD) in adults |
| starting_dose | String | Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h |
| preparations | String | 100 mg/20 mL vial, single-use |
| fda_max | String | Single 60-hour course |
| pill_id | Text | |
| routes | List of String, delimiter: , | Intravenous (continuous infusion in a REMS-certified facility) |
| onset | String | Antidepressant effect within hours of infusion start; sustained at 30 days |
| duration | String | Single infusion course |
| halflife | String | ~9 hours (terminal) |
| bioavailability | String | 100% (IV) |
| pregnancy | String | Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered |
| legal | String | Rx; REMS program required (excessive sedation/loss of consciousness during infusion) |