Page values for "Buprenorphine"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Buprenorphine |
| brand | String | |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Opioid analgesics|Opioid analgesic (partial mu-agonist • kappa antagonist)]] • [[:Category:Schedule III controlled substances|Schedule III controlled substance]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-0000004B-QINU`"', '"`UNIQ--vote-0000004C-QINU`"', '"`UNIQ--vote-0000004D-QINU`"', '"`UNIQ--vote-0000004E-QINU`"' |
| starting_dose | String | |
| preparations | String | |
| fda_max | String | MOUD: typical effective max 24 mg/day sublingual (doses above offer limited additional mu-occupancy due to ceiling). Pain (Belbuca): 900 mcg every 12 hours. |
| pill_id | Text | |
| routes | List of String, delimiter: , | Sublingual (primary for MOUD) • buccal (Belbuca for pain) • transdermal (Butrans) • SC depot (Sublocade) • IV/IM (Buprenex). Oral swallowed: very low bioavailability due to first-pass; not therapeutic. |
| onset | String | Sublingual analgesic effect 30-60 minutes; MOUD craving suppression within hours; Butrans patch steady-state in 3 days. |
| duration | String | MOUD: 24-72 hours per sublingual dose (long; permits every-other-day or three-times-weekly dosing in stable patients); Butrans patch: 7 days; Sublocade depot: 28+ days; Buprenex IV/IM: 6-8 hours. |
| halflife | String | Buprenorphine sublingual: 24-42 hours (long, contributes to extended dosing intervals). Norbuprenorphine (active metabolite, weaker mu-agonist): 24-48 hours.'"`UNIQ--ref-0000004F-QINU`"' |
| bioavailability | String | ~30% (sublingual; the primary therapeutic route); ~10-20% (oral swallowed, low due to first-pass); ~50% (buccal Belbuca); transdermal Butrans bypasses first-pass.'"`UNIQ--ref-00000050-QINU`"' |
| pregnancy | String | |
| legal | String |