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Page values for "Carbamazepine"

From Pharmacopedia
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"Medicines" values

1 row is stored for this page
FieldField typeValue
genericStringCarbamazepine
brandStringTegretol (IR, XR, suspension), Carbatrol (ER), Equetro (ER for bipolar), Epitol
structureFile
classesList of String, delimiter: ,[[:Category:Anticonvulsants|Anticonvulsant]] [[:Category:Mood stabilizers|Mood stabilizer]] [[:Category:Sodium channel blockers|Sodium channel blocker]]
mechanismString
usesString'"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"'
starting_doseStringSeizures: 200 mg PO BID, titrate by 200 mg/week to 800-1200 mg/day. Trigeminal neuralgia: 100-200 mg BID, titrate to 200-400 mg TID. Bipolar: 200 mg BID, titrate to 1600 mg/day
preparationsStringIR tablets 200 mg; chewable 100 mg; oral suspension 100 mg/5 mL; XR tablets 100, 200, 400 mg (Tegretol XR); ER capsules 100, 200, 300 mg (Carbatrol, Equetro)
fda_maxString1200 mg/day (adult seizures); 1600 mg/day (bipolar mania)
pill_idText
routesList of String, delimiter: ,Oral
onsetStringAnticonvulsant effect within days; trigeminal neuralgia relief 24-72 hours; mood-stabilizing effect over weeks
durationStringBID-QID dosing (IR); BID for ER formulations
halflifeString'''Autoinduction''': 25-65 hours initially, falling to 12-17 hours after 2-3 weeks of dosing as carbamazepine induces its own CYP3A4 metabolism. Major clinical implication: doses require re-titration after the autoinduction period'"`UNIQ--ref-0000001D-QINU`"'
bioavailabilityString~80% (oral)'"`UNIQ--ref-0000001E-QINU`"'
pregnancyString'''Substantial teratogenic risk''' including neural tube defects, craniofacial malformations, cardiac defects, and growth restriction; folic acid supplementation and effective contraception are required in reproductive-age patients'"`UNIQ--ref-0000001F-QINU`"'
legalString[[USLegal:Prescription only|Rx-only]] in US