Page values for "Lamotrigine"

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"Medicines" values

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Field	Field type	Value
generic	`String`	Lamotrigine
brand	`String`	Lamictal (IR), Lamictal XR, Lamictal ODT
structure	`File`
classes	List of `String`, delimiter: `,`	[[:Category:Anticonvulsants\|Anticonvulsant]] • [[:Category:Mood stabilizers\|Mood stabilizer]] • [[:Category:Sodium channel blockers\|Sodium channel blocker]]
mechanism	`String`
uses	`String`	'"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"'
starting_dose	`String`
preparations	`String`	IR tablets 25, 100, 150, 200 mg; chewable dispersible tablets 2, 5, 25 mg; ODT 25, 50, 100, 200 mg; XR tablets 25, 50, 100, 200, 250, 300 mg
fda_max	`String`	400 mg/day (bipolar monotherapy); 700 mg/day (epilepsy with enzyme-inducing comedication)
pill_id	`Text`
routes	List of `String`, delimiter: `,`	Oral
onset	`String`	Antiepileptic effect within days at therapeutic level; mood-stabilizing effect emerges over weeks
duration	`String`	24 hours (often divided BID at higher doses)
halflife	`String`	~25-33 hours alone; ~15 hours with enzyme inducers; '''≥60 hours with valproate''' (UGT inhibition)'"`UNIQ--ref-00000025-QINU`"'
bioavailability	`String`	~98% (oral)'"`UNIQ--ref-00000026-QINU`"'
pregnancy	`String`	'''Among the safest mood stabilizers in pregnancy''' with reassuring monotherapy registry data, in sharp contrast to valproate. Estrogen-containing contraceptives accelerate lamotrigine metabolism, requiring dose adjustments at start and stop of contraception'"`UNIQ--ref-00000027-QINU`"'
legal	`String`	[[USLegal:Prescription only\|Rx-only]] in US. Carries the FDA '''Boxed Warning for serious skin reactions''' including Stevens-Johnson syndrome and toxic epidermal necrolysis, with the risk concentrated in the first 2-8 weeks of therapy and elevated by rapid titration'"`UNIQ--ref-00000028-QINU`"'