Page values for "Losartan"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Losartan |
| brand | String | Cozaar |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] • [[:Category:Antihypertensives|Antihypertensive]] |
| mechanism | String | '"`UNIQ--vote-000000B6-QINU`"' Active metabolite EXP3174 is ~10-40-fold more potent than the parent and accounts for most of the antihypertensive effect; CYP2C9 polymorphism affects conversion'"`UNIQ--ref-000000B7-QINU`"'. |
| uses | String | '"`UNIQ--vote-000000B8-QINU`"', '"`UNIQ--vote-000000B9-QINU`"', '"`UNIQ--vote-000000BA-QINU`"', '"`UNIQ--vote-000000BB-QINU`"' |
| starting_dose | String | 50 mg PO daily (25 mg in volume depletion or hepatic impairment) |
| preparations | String | 25 mg, 50 mg, 100 mg tablets |
| fda_max | String | 100 mg/d |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | BP effect 1-2 weeks; antihypertensive peak 3-6 weeks |
| duration | String | 24 hours |
| halflife | String | 2 hours (parent); 6-9 hours for active carboxylic acid metabolite EXP3174'"`UNIQ--ref-000000BC-QINU`"' |
| bioavailability | String | ~33% (extensive first-pass via CYP2C9 and CYP3A4)'"`UNIQ--ref-000000BD-QINU`"' |
| pregnancy | String | '''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-000000BE-QINU`"' |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |