Page values for "Nuedexta"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Dextromethorphan / Quinidine |
| brand | String | Nuedexta |
| structure | File | |
| classes | List of String, delimiter: , | |
| mechanism | String | '"`UNIQ--vote-00001580-QINU`"' First FDA-approved treatment for PBA. The 10 mg quinidine daily dose is far below antiarrhythmic levels but sufficient to nearly fully inhibit CYP2D6, the basis of the combination's pharmacokinetic rationale'"`UNIQ--ref-00001581-QINU`"'. |
| uses | String | '"`UNIQ--vote-00001582-QINU`"' |
| starting_dose | String | 1 capsule (20/10 mg dextromethorphan/quinidine) PO once daily × 7 days, then 1 capsule BID |
| preparations | String | 20 mg dextromethorphan HBr / 10 mg quinidine sulfate capsules |
| fda_max | String | 1 capsule BID (40 mg DXM / 20 mg quinidine per day) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | PBA episode reduction within 1-2 weeks |
| duration | String | 12 hours |
| halflife | String | Dextromethorphan substantially prolonged by quinidine's CYP2D6 inhibition (typical extensive metabolizers see ~10× higher AUC); quinidine ~6-8 hours'"`UNIQ--ref-00001583-QINU`"' |
| bioavailability | String | Increased substantially via CYP2D6 inhibition'"`UNIQ--ref-00001584-QINU`"' |
| pregnancy | String | Limited data; quinidine has been used in pregnancy as antiarrhythmic.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Caution with QT-prolonging medicines (quinidine itself is class IA antiarrhythmic, and the dose here, though sub-antiarrhythmic, still contributes to QT)'"`UNIQ--ref-00001585-QINU`"' |