Page values for "Primidone"
From Pharmacopedia
More actions
"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Primidone |
| brand | String | Mysoline |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Anticonvulsants|Anticonvulsant]] • [[:Category:Barbiturates|Barbiturate (parent compound)]] • [[:Category:Tremor medicines|Tremor medicine]] |
| mechanism | String | '"`UNIQ--vote-00000013-QINU`"' Strong CYP3A4 induction via the phenobarbital metabolite produces many interactions (reduces oral contraceptives, warfarin, many psychotropics). Essential-tremor efficacy is the unique pharmacological selling point'"`UNIQ--ref-00000014-QINU`"'. |
| uses | String | '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' |
| starting_dose | String | Seizures: 100-125 mg PO at bedtime x 3 days, then BID, then TID, escalating to 750-1500 mg/day. Essential tremor: 25-50 mg PO at bedtime, titrate slowly to 250-750 mg/day |
| preparations | String | Tablets 50, 250 mg |
| fda_max | String | 2 g/day (seizures); typically much lower for essential tremor |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Anticonvulsant effect emerges with slow titration over weeks; tremor effect over weeks |
| duration | String | BID-TID dosing |
| halflife | String | Primidone 5-15 hours; '''phenobarbital active metabolite 50-150 hours'''; PEMA (phenylethylmalonamide) active metabolite 16 hours'"`UNIQ--ref-00000017-QINU`"' |
| bioavailability | String | ~90% (oral)'"`UNIQ--ref-00000018-QINU`"' |
| pregnancy | String | Substantial teratogenic signal (barbiturate class effects including neonatal withdrawal and hemorrhagic disease of newborn).<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. '''Federally non-controlled despite being a barbiturate''', a paradoxical situation given that its primary active metabolite phenobarbital is Schedule IV'"`UNIQ--ref-00000019-QINU`"' |