Page values for "Simvastatin"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Simvastatin |
| brand | String | Zocor |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Statins|Statin]] • [[:Category:Lipid-lowering_agents|Lipid-lowering agent]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-00000178-QINU`"', '"`UNIQ--vote-00000179-QINU`"' |
| starting_dose | String | 10-20 mg PO once daily in the evening (40 mg starting allowed for high CV risk) |
| preparations | String | 5, 10, 20, 40, 80 mg tablets; 4 mg/mL oral suspension |
| fda_max | String | 40 mg/d standard; 80 mg/d restricted to patients tolerating 80 mg for ≥12 months without myopathy (post-SEARCH 2011 FDA restriction) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | LDL lowering at 2 weeks, max by 4 weeks |
| duration | String | 24 hours (evening dosing aligns with overnight HMG-CoA reductase peak) |
| halflife | String | ~2 hours (parent and active β-hydroxy acid metabolite); pharmacodynamic effect lasts 24 hours via target turnover'"`UNIQ--ref-0000017A-QINU`"' |
| bioavailability | String | <5% (extensive hepatic first-pass; statin pharmacology is hepatocellular, not systemic)'"`UNIQ--ref-0000017B-QINU`"' |
| pregnancy | String | Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |