Page values for "Brexanolone"

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"Medicines" values

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Field	Field type	Value
generic	`String`
brand	`String`	Zulresso
structure	`File`
classes	List of `String`, delimiter: `,`	Neuroactive steroid • GABA-A positive allosteric modulator
mechanism	`String`
uses	`String`	Postpartum depression (PPD) in adults
starting_dose	`String`	Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h
preparations	`String`	100 mg/20 mL vial, single-use
fda_max	`String`	Single 60-hour course
pill_id	`Text`
routes	List of `String`, delimiter: `,`	Intravenous (continuous infusion in a REMS-certified facility)
onset	`String`	Antidepressant effect within hours of infusion start; sustained at 30 days
duration	`String`	Single infusion course
halflife	`String`	~9 hours (terminal)
bioavailability	`String`	100% (IV)
pregnancy	`String`	Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered
legal	`String`	Rx; REMS program required (excessive sedation/loss of consciousness during infusion)