1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Diphenhydramine (hydrochloride; citrate) |
| brand | String | Benadryl (oral, injectable, topical), Banophen, Sominex (sleep aid), ZzzQuil, Aler-Dryl |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Antihistamines|First-generation antihistamine (ethanolamine)]] • [[:Category:Anticholinergics|Anticholinergic]] • [[:Category:Sleep aids|Sleep aid]] • [[:Category:Antiemetics|Antiemetic]] |
| mechanism | String | '"`UNIQ--vote-0000001D-QINU`"' Major Beers-list concern in elderly patients for cognitive and fall risks. CYP2D6 substrate. At massive overdose, also produces sodium channel blockade with cardiac toxicity'"`UNIQ--ref-0000001E-QINU`"'.
'"`UNIQ--effect-0000001F-QINU`"' |
| uses | String | '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' |
| starting_dose | String | Allergy: 25-50 mg PO every 4-6 hours. Insomnia: 25-50 mg PO at bedtime. IV (acute dystonia, severe allergic reaction): 25-50 mg slow IV push |
| preparations | String | Tablets 25, 50 mg; capsules; liquid; chewable; topical cream/gel; injection 50 mg/mL |
| fda_max | String | 300 mg/day (oral) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IV • IM • topical |
| onset | String | 15-30 minutes (oral); 1-2 minutes (IV) |
| duration | String | 4-6 hours |
| halflife | String | 4-8 hours (longer in elderly, 9-13 hours)'"`UNIQ--ref-00000026-QINU`"' |
| bioavailability | String | ~40-60% (oral, with significant first-pass)'"`UNIQ--ref-00000027-QINU`"' |
| pregnancy | String | Older agent with substantial use experience; broadly considered safe in pregnancy'"`UNIQ--ref-00000028-QINU`"' |
| legal | String | [[USLegal:Over-the-counter|OTC]] for most oral and topical formulations; [[USLegal:Prescription only|Rx-only]] for injectable |
