1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Esomeprazole |
| brand | String | Nexium, Nexium 24HR (OTC) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Proton_pump_inhibitors|Proton pump inhibitor (PPI)]] • [[:Category:Antisecretory_agents|Gastric acid suppressant]] |
| mechanism | String | '"`UNIQ--vote-000008E1-QINU`"' Like omeprazole, it is an acid-activated prodrug that covalently and irreversibly binds the H+/K+ ATPase. CYP2C19 PGx remains clinically relevant for both'"`UNIQ--ref-000008E2-QINU`"'. |
| uses | String | '"`UNIQ--vote-000008E3-QINU`"', '"`UNIQ--vote-000008E4-QINU`"', '"`UNIQ--vote-000008E5-QINU`"', '"`UNIQ--vote-000008E6-QINU`"', '"`UNIQ--vote-000008E7-QINU`"' |
| starting_dose | String | 20-40 mg PO once daily, 30-60 minutes before breakfast |
| preparations | String | 20, 40 mg delayed-release capsules; 2.5, 5, 10, 20, 40 mg oral suspension packets; 20, 40 mg IV |
| fda_max | String | 40 mg/d typical; up to 240 mg/d for Zollinger-Ellison |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IV |
| onset | String | Acid suppression within hours; full effect after 3-5 days of dosing |
| duration | String | 24-72 hours per dose (irreversible enzyme binding) |
| halflife | String | ~1.5 hours (plasma); pharmacodynamic effect 24+ hours via target turnover'"`UNIQ--ref-000008E8-QINU`"' |
| bioavailability | String | ~64-90% (oral; increases at higher doses and with multi-day dosing)'"`UNIQ--ref-000008E9-QINU`"' |
| pregnancy | String | Widely used in obstetric reflux; reassuring data.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | OTC (20 mg, 14-day course) and [[USLegal:Prescription only|Rx-only]] (higher and longer durations) in US |
