1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Estradiol (17β-estradiol) |
| brand | String | Estrace, Vivelle-Dot, Climara, Divigel, Evamist, Estring, Estraderm, Premarin (CEE, not strictly estradiol) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Estrogens|Estrogen]] • [[:Category:Sex_hormones|Sex hormone]] • [[:Category:Hormone_replacement_therapy|Hormone replacement therapy]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-000003B5-QINU`"', '"`UNIQ--vote-000003B6-QINU`"', '"`UNIQ--vote-000003B7-QINU`"', '"`UNIQ--vote-000003B8-QINU`"', '"`UNIQ--vote-000003B9-QINU`"' |
| starting_dose | String | Oral 1-2 mg daily; transdermal patch 0.025-0.05 mg/d twice weekly; transdermal gel 0.5-1 g/d; vaginal 10 mcg tablet twice weekly for GSM. Always combine with a progestogen in patients with an intact uterus. |
| preparations | String | Oral 0.5, 1, 2 mg tablets; transdermal patches (twice-weekly and once-weekly); 0.06% gel; 1.53 mg/spray topical; vaginal ring (Estring); vaginal tablet (Vagifem/Yuvafem); vaginal cream |
| fda_max | String | Indication-specific; lowest effective dose for shortest duration is the WHI-era standard |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • transdermal • vaginal • IM (estradiol valerate • cypionate) |
| onset | String | Vasomotor relief 2-4 weeks; bone density gains over months |
| duration | String | Route- and formulation-dependent |
| halflife | String | ~13-20 hours (oral); transdermal pharmacokinetics buffer the peaks/troughs of oral dosing'"`UNIQ--ref-000003BA-QINU`"' |
| bioavailability | String | Oral ~5% (extensive first-pass to estrone and conjugates); transdermal bypasses first-pass, giving more physiologic estradiol:estrone ratio'"`UNIQ--ref-000003BB-QINU`"' |
| pregnancy | String | Contraindicated in pregnancy (use is not appropriate during gestation; class label X). Lactation considerations vary by indication.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |
