1 row is stored for this page
| Field | Field type | Value |
|---|
| generic | String | Guanfacine |
| brand | String | Intuniv (extended-release), Tenex (immediate-release) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Alpha-2 adrenergic agonists|Alpha-2 adrenergic agonist]] • [[:Category:ADHD medicines|ADHD medicine]] • [[:Category:Antihypertensives|Antihypertensive (historical)]] |
| mechanism | String | '"`UNIQ--vote-00000019-QINU`"' Sedation and hypotension are the dose-limiting effects; gradual titration and bedtime or split dosing mitigate both. Abrupt discontinuation can precipitate rebound hypertension, particularly with long-standing use'"`UNIQ--ref-0000001A-QINU`"'. |
| uses | String | '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' |
| starting_dose | String | Intuniv ER 1 mg PO once daily; titrate by 1 mg/week as tolerated to clinical response |
| preparations | String | Extended-release tablets 1, 2, 3, 4 mg (Intuniv); immediate-release tablets 1, 2 mg (Tenex) |
| fda_max | String | 7 mg/day in children and adolescents; weight-based ceiling (~0.12 mg/kg/day) applies in smaller patients |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Gradual; full clinical effect over 2-4 weeks of titration |
| duration | String | ~24 hours (ER formulation supports once-daily dosing) |
| halflife | String | ~17-18 hours (Intuniv ER); ~17 hours (immediate-release)'"`UNIQ--ref-00000020-QINU`"' |
| bioavailability | String | ~58% (extended-release); ~80% (immediate-release)'"`UNIQ--ref-00000021-QINU`"' |
| pregnancy | String | Limited human data. Animal studies show fetal effects at maternally toxic doses; use only if benefits justify the potential risk.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, which is a meaningful contrast to the psychostimulant alternatives for ADHD'"`UNIQ--ref-00000022-QINU`"' |
