Apply thin layer to hyperpigmented areas BID; limit to 4-6 month courses to avoid ochronosis
preparations
String
4% prescription cream/lotion; OTC 2% withdrawn in US (2020 CARES Act); compounded higher strengths available
fda_max
String
4% topical; limit duration of use
pill_id
Text
routes
List of String, delimiter: ,
Topical
onset
String
Visible lightening at 4-12 weeks
duration
String
Hours per application
halflife
String
Not meaningfully described — topical local action with minimal systemic absorption'"`UNIQ--ref-00001218-QINU`"'
bioavailability
String
Topical with limited but measurable systemic absorption'"`UNIQ--ref-00001219-QINU`"'
pregnancy
String
Generally avoided in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup>
legal
String
[[USLegal:Prescription only|Rx-only]] in US since 2020 (OTC 2% formulations withdrawn under CARES Act due to safety concerns)
