Page values for "Methylprednisolone"
From Pharmacopedia
More actions
"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Methylprednisolone |
| brand | String | Medrol (oral), Solu-Medrol (IV/IM), Depo-Medrol (depot injection) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Corticosteroids|Corticosteroid]] • [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]] • [[:Category:Immunosuppressants|Immunosuppressant]] |
| mechanism | String | '"`UNIQ--vote-00000860-QINU`"' Activates the glucocorticoid receptor to broadly remodel inflammatory, immune, and metabolic transcription. Unlike prednisone, it does not require hepatic activation, making it the preferred oral choice in severe hepatic dysfunction'"`UNIQ--ref-00000861-QINU`"'. |
| uses | String | '"`UNIQ--vote-00000862-QINU`"', '"`UNIQ--vote-00000863-QINU`"', '"`UNIQ--vote-00000864-QINU`"', '"`UNIQ--vote-00000865-QINU`"', '"`UNIQ--vote-00000866-QINU`"' |
| starting_dose | String | PO Medrol Dosepak (5-day taper from 24 mg to 4 mg) is the prototypic short-course outpatient regimen; IV pulse 1 g daily for 3-5 days for MS relapse; intra-articular 4-80 mg per joint q1-5 weeks |
| preparations | String | 2, 4, 8, 16, 32 mg oral tablets; 40, 125, 500, 1000 mg IV vials; Depo-Medrol 20, 40, 80 mg/mL IM depot |
| fda_max | String | Indication-specific |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IM • IV • intra-articular • intrathecal (rare and controversial) |
| onset | String | IV pulse: hours; PO: hours; intra-articular: days |
| duration | String | Biologic 12-36 hours (intermediate-acting); Depo-Medrol depot weeks |
| halflife | String | Plasma 2-3 hours; biologic ~18-36 hours'"`UNIQ--ref-00000867-QINU`"' |
| bioavailability | String | ~80-99% (oral)'"`UNIQ--ref-00000868-QINU`"' |
| pregnancy | String | Use when benefits outweigh; small association with oral clefts in first trimester debated.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |