Page values for "Spironolactone"
From Pharmacopedia
More actions
"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Spironolactone |
| brand | String | Aldactone, CaroSpir |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Aldosterone_antagonists|Mineralocorticoid (aldosterone) receptor antagonist]] • [[:Category:Potassium-sparing_diuretics|Potassium-sparing diuretic]] • [[:Category:Antiandrogens|Antiandrogen]] |
| mechanism | String | |
| uses | String | '"`UNIQ--vote-0000034F-QINU`"', '"`UNIQ--vote-00000350-QINU`"', '"`UNIQ--vote-00000351-QINU`"', '"`UNIQ--vote-00000352-QINU`"', '"`UNIQ--vote-00000353-QINU`"' |
| starting_dose | String | 25 mg PO once daily for HFrEF and primary aldosteronism; up to 100 mg/d for ascites; 50-200 mg/d for hirsutism |
| preparations | String | 25 mg, 50 mg, 100 mg tablets; 25 mg/5 mL oral suspension (CaroSpir) |
| fda_max | String | 400 mg/d (acute primary aldosteronism diagnosis); 100-200 mg/d typical chronic |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Natriuresis at 2-3 days; endocrine effects (gynecomastia, antiandrogen action) over weeks |
| duration | String | Variable; biologically active metabolite carries effect beyond plasma half-life |
| halflife | String | 1.4 hours (parent); 13-24 hours for active metabolite canrenone'"`UNIQ--ref-00000354-QINU`"' |
| bioavailability | String | ~70% (oral; bioavailability and absorption are improved with food)'"`UNIQ--ref-00000355-QINU`"' |
| pregnancy | String | Avoid in pregnancy; antiandrogen effects can feminize a male fetus.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |