Page values for "Valacyclovir"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Valacyclovir |
| brand | String | Valtrex |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Antivirals|Antiviral]] • [[:Category:Nucleoside_analogs|Nucleoside analog (prodrug)]] • [[:Category:Anti-herpesvirus_agents|Anti-herpesvirus agent]] |
| mechanism | String | '"`UNIQ--vote-000005D0-QINU`"' Selectivity comes from the viral-kinase-only initial phosphorylation step, which is why uninfected cells generate minimal active drug'"`UNIQ--ref-000005D1-QINU`"'. Dose-adjust by renal function; rare crystalline nephropathy with rapid IV acyclovir. |
| uses | String | '"`UNIQ--vote-000005D2-QINU`"', '"`UNIQ--vote-000005D3-QINU`"', '"`UNIQ--vote-000005D4-QINU`"', '"`UNIQ--vote-000005D5-QINU`"' |
| starting_dose | String | Initial genital herpes 1 g PO BID × 10 days; recurrent 500 mg BID × 3 days; suppression 500 mg-1 g PO daily; zoster 1 g TID × 7 days |
| preparations | String | 500 mg, 1 g tablets |
| fda_max | String | 3 g/d (zoster) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral |
| onset | String | Symptom relief within 24-48 hours |
| duration | String | 8 hours per dose |
| halflife | String | ~3 hours (acyclovir, the active metabolite); longer in renal impairment'"`UNIQ--ref-000005D6-QINU`"' |
| bioavailability | String | ~55% bioavailability of acyclovir after valacyclovir oral (vs ~20% from oral acyclovir directly)'"`UNIQ--ref-000005D7-QINU`"' |
| pregnancy | String | Widely used in pregnancy when antiviral indicated; reassuring registry data.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US |