Page values for "Valproate"
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"Medicines" values
1 row is stored for this page| Field | Field type | Value |
|---|---|---|
| generic | String | Valproate (valproic acid, divalproex sodium, sodium valproate) |
| brand | String | Depakote, Depakote ER, Depakene, Depacon (IV) |
| structure | File | |
| classes | List of String, delimiter: , | [[:Category:Antiepileptics|Antiepileptic]] • [[:Category:Mood_stabilizers|Mood stabilizer]] • [[:Category:Migraine_prophylaxis|Migraine prophylaxis]] |
| mechanism | String | '"`UNIQ--vote-00000975-QINU`"' Hyperammonemic encephalopathy (consider in any unexplained CNS depression), thrombocytopenia, and polycystic ovary syndrome are characteristic chronic-use adverse effects beyond hepatic and pancreatic risks'"`UNIQ--ref-00000976-QINU`"'. |
| uses | String | '"`UNIQ--vote-00000977-QINU`"', '"`UNIQ--vote-00000978-QINU`"', '"`UNIQ--vote-00000979-QINU`"', '"`UNIQ--vote-0000097A-QINU`"', '"`UNIQ--vote-0000097B-QINU`"' |
| starting_dose | String | Seizures: 10-15 mg/kg/d divided BID-TID, titrate to therapeutic level (50-100 mcg/mL); bipolar mania: 750 mg/d divided, titrate |
| preparations | String | 125, 250, 500 mg delayed-release tablets (Depakote); 250, 500 mg ER tablets (Depakote ER); 125, 250 mg sprinkle capsules; 250 mg/5 mL syrup; 500 mg IV (Depacon) |
| fda_max | String | 60 mg/kg/d (typically up to 3000 mg/d) |
| pill_id | Text | |
| routes | List of String, delimiter: , | Oral • IV • rectal (off-label use of injection) |
| onset | String | Anticonvulsant effect within days; mood-stabilizing effect 1-3 weeks |
| duration | String | 12 hours (IR); 24 hours (ER) |
| halflife | String | 9-16 hours'"`UNIQ--ref-0000097C-QINU`"' |
| bioavailability | String | ~100% (oral); highly (~90%) protein-bound, with non-linear binding above therapeutic levels (free fraction matters clinically in hypoalbuminemia)'"`UNIQ--ref-0000097D-QINU`"' |
| pregnancy | String | '''Contraindicated for migraine prophylaxis in pregnancy; high teratogenic risk''' (neural tube defects, craniofacial anomalies, cardiac defects, cognitive/IQ impairment); avoid in women of childbearing potential without reliable contraception when alternatives exist'"`UNIQ--ref-0000097E-QINU`"' |
| legal | String | [[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warnings''' for hepatotoxicity (especially children <2 with metabolic disorders), teratogenicity, and pancreatitis'"`UNIQ--ref-0000097F-QINU`"' |